Oral mucosa transplantation may improve tear film osmolarity in dogs with keratoconjunctivitis sicca - a preliminary study

ABSTRACT The objective of this study was to evaluate the use cyclosporine 1% alone or associated with oral mucosa transplantation (OMT) in dogs dry keratoconjunctivitis (KCS). Schirmer Tear Test (STT-1) and Film Osmolarity (TFO) were measured both eyes 30 adult (before 45 days after treatment. animals divided into three groups (10 for group): control (normal dogs), group I (GI, treated alone), II (GII, OMT). All STT-1 TFO values subjected Shapiro-Wilk normality test, all normally distributed. before treatment T-Student Test. STT‐1 right eye Repeated Measures ANOVA followed by a Tukey comparison between II. Means value p≤0.05 considered significant. There decreased osmolarity Mean GII (322.60±16.56 mOsm/L) significantly lower than GI (336.40±5.66 mOsm/L). OMT improved tear film KCS seeming synergism clinical surgical treatments.